Esteves GNN, Ferraz LS, Alvarez MMP, Costa CA, Mello RL, Tersariol ILS, Rodrigues T* (2020) BRAF and NRAS mutated melanoma: Different Ca2+ responses, Na+/Ca2+ exchanger expression, and sensitivity to inhibitors. Cell Calcium, 90:102241. doi: 10.1016/j.ceca.2020.102241.
Ferraz LS, Costa RT, Costa CA, Ribeiro CAJ, Arruda DC, Maria-Engler SS, Rodrigues T* (2020) Targeting mitochondria in melanoma: interplay between MAPK signaling pathway and mitochondrial dynamics. Biochemical Pharmacology, 178:114104. doi: 10.1016/j.bcp.2020.114104.
Rodrigues T*, FerrazLS (2020) Therapeutic potential of targeting mitochondrial dynamics in cancer. Biochemical Pharmacology, 182:114282, 2020.
Costa CA, Lopes RM, Ferraz LS, Esteves GNN, Di Iorio JF, Souza AA, de Oliveira IM, Manarin F, Judice WAS, Stefani HA, Rodrigues T* (2020) Cytotoxicity of 4-substituted quinoline derivatives: Anticancer and antileishmanial potential. Bioorg Med Chem, 28(11):115511. doi: 10.1016/j.bmc.2020.115511.
Medeiros HCD, Colturato-Kido C, Ferraz LS, Costa CA, Moraes VWR, Paredes-Gamero EJ, Tersariol ILS, Rodrigues T* (2019) AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia. Chemico-Biological Interactions, 315:108888. doi: 10.1016/j.cbi.2019.108888.
Rodrigues T*, Estevez GNN, Tersariol ILS (2019) Na+/Ca2+ exchangers: Unexploited opportunities for cancer therapy? Biochemical Pharmacology, 163:357-361. doi: 10.1016/j.bcp.2019.02.032.
Lucena SV, Moura GEDD, Rodrigues T, Watashi CM, Melo FH, Icimoto MY, Viana GM, Nader HB, Monteiro HP, Tersariol ILS, Ogata FT (2018) Heparan sulfate proteoglycan deficiency up-regulates the intracellular production of nitric oxide in Chinese hamster ovary cell lines. J. Cell. Physiol., 233(4):3176-3194. doi: 10.1002/jcp.26160.
Mello JC, Moraes VW, Watashi CM, da Silva DC, Cavalcanti LP, Franco MK, Yokaichiya F, de Araujo DR, Rodrigues T* (2016) Enhancement of chlorpromazine antitumor activity by Pluronics F127/L81 nanostructured system against human multidrug resistant leukemia. Pharmacological Research, 111:102-112. doi: 10.1016/j.phrs.2016.05.032.
Jabes DL, de Freitas Oliveira AC, Alencar VC, Menegidio FB, Reno DL, Santos DS, Barbosa DA, Vilas Boas RO, de Oliveira Rodrigues Cunha RL, Rodrigues T, Costa de Oliveira R, Nunes LR. (2016) Thioridazine inhibits gene expression control of the cell wall signaling pathway (CWI) in the human pathogenic fungus Paracoccidioides brasiliensis. Mol. Genet. Genomics, 291(3):1347-62. doi: 10.1007/s00438-016-1184-1.
De Faria PA, Bettanin F, Cunha RLOR, Paredes-Gamero EJ, Homem-de-Melo P, Nantes IL, Rodrigues T* (2015) Cytotoxicity of phenothiazine derivatives associated with mitochondrial dysfunction: A structure-activity investigation. Toxicology (Amsterdam), 330:44-54. doi: 10.1016/j.tox.2015.02.004.
Moraes VWR, Caires ACF, Paredes-Gamero EJ, Rodrigues T* (2013) Organopalladium compound 7b targets mitochondrial thiols and induces caspase-dependent apoptosis in human myeloid leukemia cells. Cell Death & Disease, 4(6):e658. doi: 10.1038/cddis.2013.190.
Guimarães NS, Mello JC, Paiva JS, Bueno PC, Berretta AA, Torquato RJ, Nantes IL, Rodrigues T. (2012) Baccharis dracunculifolia, the main source of green propolis, exhibits potent antioxidant activity and prevents oxidative mitochondrial damage. Food Chem Toxicol, 50(3-4):1091-7. doi: 10.1016/j.fct.2011.11.014.
Cruz TS, Faria PA, Santana DP, Ferreira JC, Oliveira V, Nascimento OR, Cerchiaro G, Curti C, Nantes IL, Rodrigues T* (2010) On the mechanisms of phenothiazine-induced mitochondrial permeability transition: Thiol oxidation, strict Ca2+-dependence, and cyt c release. Biochemical Pharmacology, 80(8):1284-95. doi: 10.1016/j.bcp.2010.06.052.
Santana DP, Faria PA, Paredes-Gamero EJ, Caires AC, Nantes IL, Rodrigues T. (2009) Palladacycles catalyse the oxidation of critical thiols of the mitochondrial membrane proteins and lead to mitochondrial permeabilization and cytochrome c release associated with apoptosis. Biochemical Journal, 417(1):247-56. doi: 10.1042/BJ20080972.
Rodrigues T, de França LP, Kawai C, de Faria PA, Mugnol KC, Braga FM, Tersariol IL, Smaili SS, Nantes IL (2007) Protective role of mitochondrial unsaturated lipids on the preservation of the apoptotic ability of cytochrome C exposed to singlet oxygen. J Biol Chem, 282(35):25577-87. doi: 10.1074/jbc.M700009200.
Rodrigues T, dos Santos CG, Riposati A, Barbosa LR, Di Mascio P, Itri R, Baptista MS, Nascimento OR, Nantes IL (2006) Photochemically generated stable cation radical of phenothiazine aggregates in mildly acid buffered solutions. J Phys Chem B, 110(25):12257-65. doi: 10.1021/jp0605404.
Rodrigues T, Santos AC, Pigoso AA, Mingatto FE, Uyemura SA, Curti C (2002) Thioridazine interacts with membrane of mitochondria acquiring antioxidant activity toward apoptosis-potentially implicated mechanisms. British Journal of Pharmacology, London, 136(1):136-42. doi: 10.1038/sj.bjp.0704672.